Metsulfuron-methyl is a sulfonylurea herbicide widely used for its efficacy in controlling a variety of broadleaf weeds and some grasses. Understanding its mode of action is crucial for effective application and resistance management.

metsulfuron methyl mode of action

1. Inhibition of ALS Enzyme:

   • Metsulfuron-methyl works by inhibiting the enzyme acetolactate synthase (ALS), also known as acetohydroxyacid synthase (AHAS). ALS is crucial for the synthesis of branched-chain amino acids (valine, leucine, and isoleucine) in plants.
   • The inhibition of ALS leads to the cessation of cell division and growth in the meristematic regions of the plant, ultimately resulting in plant death.

2. Selective Activity:

   • Metsulfuron-methyl is selective, meaning it primarily affects broadleaf weeds and some grass species while being safe for certain crops when used at recommended rates.
   • The selectivity is due to differences in the uptake, translocation, and metabolism of the herbicide between crops and target weeds.

3. Uptake and Translocation:

   • The herbicide is absorbed primarily through the foliage and roots of the target plants.
   • Once absorbed, metsulfuron-methyl is translocated via the plant’s xylem and phloem to the growing points, where it exerts its herbicidal action.

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